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Saturday, February 4th 2012

Childhood Glial Tumor

What’s the diagnosis?

Pleomorphic xanthoastrocytoma

A supratentorial glial tumor of childhood. Typically graded as WHO II. Imaging demonstrates a superficial, supratentorial mass with large cystic components, often with a mural nodule.

Pathology shows the tumor to be composed of spindle cells and large cells with pleomorphic nuclei with “bubbly” cyloplasm from which the term xanthomatous comes from